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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Fields Integrative Life Sciences :Cellular Network Research Organelle Pathophysiology HOME Research Laboratories Organelle Pathophysiology JAPANESE Organelle Pathophysiology Eukaryotic cells have a number of intracellular organelles with distinct functions. Interestingly enough, these organelles never function alone; they cooperatively regulate cellular homeostasis, proliferation, and differentiation, through a continuous exchange of soluble and membrane-bound molecules via membrane trafficking and/or membrane contact transfer. A failure in organelle cooperation often results in various human diseases. Our laboratory uses methods in biochemistry, cell biology, and molecular biology to identify novel organellar proteins and lipids. With these methods, we aim to unveil novel functions of organelles and the molecular mechanisms that regulate organelle cooperation. We especially focus on molecules that reside on the cytoplasmic face of the organelles; the essential face that physically interacts with other organelles and cytosol. Our results will help develop new treatments for diseases such as cancer and autoinflammatory diseases that are caused by disrupted organelle cooperation. Research Overview Intracellular organelles have unique membrane lipid compositions. This feature endows organelles with their specific functions. For example, we have shown that (1) recycling endosomes are enriched in phosphatidylserine, a class of glycerophospholipids, and regulate membrane trafficking and cellular proliferation through a variety of phosphatidylserine-binding proteins: (2) the Golgi complex is enriched in sphingomyelin, a class of sphingolipids, and functions in triggering the innate immunity signaling pathway against cytosolic DNA viruses.     Recently we have developed a novel method to identify organelle resident proteins using specific probes for organelle membrane phospholipids. This method is highly expected to reveal "unforeseen" function of intracellular organelles.   Faculty Members Professor TAGUCHI Tomohiko More ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache