スマホでカジノ

Skip to content Dept. Cancer Biology   Professor Natsuko CHIBA, MD, PhD Assistant Professor Yuki YOSHINO, MD, PhD Assistant Professor Zhenzhou FANG, MD, PhD Approximately 5% -7% of all breast cancers are inherited, and the two most important breast cancer susceptibility genes, BRCA1 and BRCA2, were identified by linkage analysis of familial breast cancers. Mutations of BRCA1 and BRCA2 have been identified in 25% of familial breast cancers. These breast cancers are collectively referred to as Hereditary Breast and Ovarian Cancer Syndrome (HBOC). In addition to hereditary cancer, it has been reported that BRCA1 is involved in a subtype of sporadic breast cancer, triple-negative breast cancer, and in the chemosensitivity of various cancers. BRCA1 is also involved in many cellular processes, including DNA repair and centrosome regulation. Defects in the regulatory mechanisms of the centrosome and DNA repair result in defective mitoses, chromosome segregation errors, and the accumulation of DNA damage, which are significant sources of genome instability, and a hallmark of cancer. Our research specifically focuses on the functions of BRCA1 in DNA repair and centrosome regulation. To analyze the functions of BRCA1 and its related proteins, we performed cytological analyses, analyses using genetically modified mice, and analyses of clinical specimens. We believe that this research will contribute to the further understanding of carcinogenesis and aid in developing novel cancer therapies.   About Us IDAC’s Mission Statement Greeting &＃038; Mission Notable Alumni History of IDAC IDAC&＃8217;s Affiliations News &＃038; Events Research Facilities &＃038; Faculty Research Facilities Common Facilities Resources &＃038; Equipment Brain Imaging Cell Center Equipment Admission &＃038; Courses Mechanisms of Aging Overcoming Intractable Cancers Overcoming Age-Related Brain Diseases Achieving &＃8220;Smart-Aging&＃8221; Public Relations &＃038; Info. Office Maps &＃038; Directions Give to IDAC Contact Us Privacy Policy &＃038; Disclaimer IDAC COVID-19 Update Navi About Us IDAC’s Mission Statement Greeting &＃038; Mission Notable Alumni History of IDAC IDAC&＃8217;s Affiliations News &＃038; Events Research Facilities &＃038; Faculty Research Facilities Common Facilities Resources &＃038; Equipment Brain Imaging Cell Center Equipment Admission &＃038; Courses Mechanisms of Aging Overcoming Intractable Cancers Overcoming Age-Related Brain Diseases Achieving &＃8220;Smart-Aging&＃8221; Public Relations &＃038; Info. Office Maps &＃038; Directions Give to IDAC Contact Us Privacy Policy &＃038; Disclaimer IDAC COVID-19 Update Navi ©Institute of Development, Aging and Cancer, Tohoku University